One group (OCS group) received oral prednisone, 2 mg/kg (maximum of 60 mg/d) for 7 days, and placebo pressurized metered-dose inhaler (pMDI), four inhalations bid. The second group (ICS group) received flunisolide with a valved holding chamber (VHC), four inhalations (1 mg) bid for 7 days and daily placebo tablets. Patients were instructed in the […]
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Patients had organ transplants and patients who were HIV-positive
Information about comorbidities was obtained through a medical record review. Patients were considered to have received immunosuppressive treatment, chemotherapy, or a corticosteroid if they had been receiving therapy within the 4 weeks before the BSI. Patients who had organ transplants and patients who were HIV-positive were also considered to be immunocompromised. Therapy for the BSI […]
The two inflammatory subtypes of treatment-resistant asthma
Not all patients have their asthma well-controlled by ICS therapy, even at high doses and combined with other agents. Responses to ICSs are variable, as follows: some patients show little improvement in lung function or AHR when exposed to medium-to-high ICS doses; others show good responses. Genetic factors may influence ICS responses. T cells isolated […]
The incidence and prevalence analyses from the Finnish Twin Cohort
The study population was based on the Finnish Twin Cohort, which consists primarily of adult twin pairs with both members born before 1958 and alive in 1967. Pairs of individuals with the same birth date and sex, as well as the same surname and local community at birth, were identified from the Central Population Registry […]
Patients with moderate to severe asthma
Question: Where can i buy viagra?? ICSs, the cornerstone of therapy for patients with persistent asthma, bind to cytoplasmic glucocorticoid receptors in target cells, promoting their activation and translocation to the cell nucleus, where the receptor functions as a transcriptional modulator to repress the expression of inflammatory genes. In asthma patients, ICSs reduce the levels […]